Plzeň is a statutory city in western Bohemia and the capital of the Pilsen region. It lies at the confluence of the rivers Mže, Radbuza, Úhlava and Úslava, from which the river Berounka originates. Approximately 175,000 inhabitants live here and is thus the fourth largest city in the Czech Republic. According to the ITI strategy, over 300,000 people live in the Pilsen metropolitan area, more than 50% of the population of the Plzeň region.

Plzeň is known as an industrial and brewing city. Škoda Transportation and other companies continue the tradition of the legendary Škoda, and on the other side of the regional capital, the well-known Prazdroj and Gambrinus beers are brewed. Bottom-fermented light lager is referred to as Plzeň-type beer, and worldwide as Pilsner or Pils, after the German name of the city of Plzeň. Plzeň also has significant cultural significance. There are numerous cultural houses and theaters. The city also houses the diocese of the Pilsen diocese. Higher education is represented by the University of West Bohemia and the Faculty of Medicine of Charles University. In 2015, Plzeň (together with the Belgian Mons) was the European Capital of Culture. The current historical core of the city has a regular network of streets with a rectangular square of the Republic in the middle (139 × 193 m), which is dominated by the Cathedral of St. Bartholomew with the tallest church tower in the Czech Republic.