Palazzo Giustinian Persico is a civil building located in the city of Venice, in the San Polo district: it overlooks the Grand Canal where it flows into the Rio di San Tomà, not far from Palazzo Tiepolo and opposite the Palazzi Mocenigo.
The Palazzo was built for the noble Giustinian family, but soon passed to the Persico family (also known as Da Persico), originally from Bergamo but joined to the patriciate for money.
The front, inspired by the work of Mauro Codussi (but not attributable to him), dates back to the 16th century: it is one of the first Venetian buildings built in the Renaissance style and as such it prefers large surfaces and essential lines. It is characterized by a lively red plaster on which two superimposed central four-light windows stand out, flanked by pairs of single-lancet windows. The frames of these holes are very valuable. The rear facade of the building, architecturally not very interesting, overlooks a large garden.