Palazzo Pesaro Papafava is a palace in Venice located in the Cannaregio district and overlooking the Canale della Misericordia (at the end of the Rio di San Felice) opposite the Scuola Grande di Santa Maria della Misericordia.
It dates back to the early fifteenth century. It was owned by the Pesaro family until the marriage of Pesarina Pesaro with Bonifacio Papafava, celebrated in 1615.
It is a building whose facade, developed on four floors, is characterized by a prevalence of Gothic elements. The expressive power of the front is concentrated in the central axis, formed by the superimposition of two four-light windows with a small balcony, of which the most valuable is the lower one. Each quadrifora is flanked by two pairs of single lancet windows, one on each side. On the ground floor there is the pointed arch water portal, flanked by four single lancet windows. The body on the left, which has round arch openings, is more recent.